Dedifferentiation and Proliferation of Mammalian Cardiomyocytes
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چکیده
منابع مشابه
Dedifferentiation and Proliferation of Mammalian Cardiomyocytes
BACKGROUND It has long been thought that mammalian cardiomyocytes are terminally-differentiated and unable to proliferate. However, myocytes in more primitive animals such as zebrafish are able to dedifferentiate and proliferate to regenerate amputated cardiac muscle. METHODOLOGY/PRINCIPAL FINDINGS Here we test the hypothesis that mature mammalian cardiomyocytes retain substantial cellular pl...
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The maintenance of self-renewal in stem cells appears to be distinct from the induction of proliferation of the terminally differentiated mammalian cardiomyocytes because it is believed that the latter are unable to divide. However, proliferation is a necessary step in both processes. Interestingly, the small molecule 6-bromoindirubin-3'-oxime (BIO) is the first pharmacological agent shown to m...
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The process of cellular differentiation culminating in terminally differentiated mammalian cells is thought to be irreversible. Here, we present evidence that terminally differentiated murine myotubes can be induced to dedifferentiate. Ectopic expression of msx1 in C2C12 myotubes reduced the nuclear muscle proteins MyoD, myogenin, MRF4, and p21 to undetectable levels in 20%-50% of the myotubes....
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̈ See article by Rucker-Martin et al. [3] (pages 38 –52) 2 . Structural remodeling of atrial myocytes in this issue. Apart from clear degenerative changes in fibrillating atria of patients which have been reported earlier by the same group and others [4,5], the present study shows that 1 . Introduction in such patients remodeling of the myocyte structure (dedifferentiation) and the surrounding c...
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Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0012559